The rapid spread of the SARS-CoV-2 virus reminds us, once more, of the porous boundaries between species, and the social and ecological disasters of growth-driven capitalism. Human dependence on diverse ways of life for collaborative survival is more obvious than ever in this time that some are calling the Sixth Extinction. In response to recent critical investigations of practices and labors of care, this collection of essays explores how attention to multispecies care contributes to recognizing the limits, dangers, and compromises of “care” practices in vulnerable ecological contexts. Taking the Sixth Extinction and its crises—of health, climate, agriculture, economy, democracy, and more—as a point of departure, the essays in this series gather diverse ethnographic stories of multispecies care to ask, How does care take form as, in, and through multispecies relations? What are the limitations and hazards of caring for nonhumans in contexts of loss and degradation? What is the potential of caring beyond the human for opening up (or disclosing) knowledge about other world-making practices and the possible ecological futures they may enable? Listening to these stories seems pertinent amid the chorus of other, often louder, voices that prophesize apocalypse and the doom of the world as we know it—or, conversely, that pronounce their unshakeable faith in solutions, in the “techno-fix” that will repair all damage through novel and ever advancing innovation.